Sounds like somthing in the background is eating away at your memory so to speak. Do you run any additional programs in the background when you play?
This may sound silly, but I myself run WinAmp in the background and listen to internet radio as I play guildwars. I know windows ME has some issues with ram, but this is only speculation.
Either way it sounds like your running low on memory as you play. I have a similar problem with a diffrent game, but I can go for hours before having to correct it, so i've never really sought a solotion to it.
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